During this course, students will learn about the applications of cell therapies in the most common hematologic malignancies. The course begins with an introductory section on hematopoiesis and on the fundamental mechanisms of the immune system functions. Various immunotherapy strategies – and specifically therapies based on CAR T cells - are detailed. The biological basis and the manufacturing process of CAR T cells are explained. Finally, clinical applications of CAR T-cell therapy in hematology are presented, in the setting of lymphoma, myeloma, and acute and chronic leukemias.